Metformin use is associated with lower mortality from bacterial sepsis and improved immunocompetence in Thai diabetes patients with acute melioidosis
Lay summary Melioidosis is a neglected tropical disease caused by the bacterium Burkholderia pseudomallei, which can be acquired from the environment through contact with soil or water. Type 2 diabetes is a major risk factor in acquiring the infection, though some past studies showed that some diabetes medications prevent deaths from melioidosis. However, although metformin is the most common treatment for diabetes, we don’t know whether it specifically prevents deaths from melioidosis.
15 Nov 2025
Environmental detection of Burkholderia pseudomallei and associated melioidosis risk: a molecular detection and case-control cohort study
Lay summary Melioidosis is a neglected tropical disease caused by the bacterium Burkholderia pseudomallei, which can be acquired from the environment through contact with soil or water. However, no previous studies established a statistically significant relationship between B. pseudomallei in the local environment and melioidosis cases, mostly because of low abundance of the bacterium and inconsistent sampling methods.
17 Jun 2025
Single-cell metabolic oscillations are pervasive and may alleviate a proteome constraint
Lay summary Biological rhythms are essential to controlling the function of living organisms. One such example is the metabolic cycle in budding yeast, which consists of cycling levels of metabolites, RNA transcripts, and oxygen consumption over time. Most studies on this cycle have been performed with chemostats, in batch-cultures. Though there are more recent studies that image cells individually, it is unclear how to reconcile finding from the two types of experiments.
26 Nov 2024